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KMID : 1234920030030010007
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Journal of Korean Oriental Association for Study of Obesity
2003 Volume.3 No. 1 p.7 ~ p.16
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Effects of β2-Adrenergic Receptor Polymorphism on Obesity
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Kim Kil-Soo
Oh Hyun-Hee
Choi Sun-Mi
Yang Hyun-Sung
Bae Jung-Hwan
Yoon Yoo-Sik
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Abstract
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Objectives: The lipolytic effects of catecholamines in adipose tissue are mediated by members of adrenergic receptors. This study was conducted to examine the effects of Gln27Glu (Q27E) polymorphism on obesity indices and risk among obesity clinic patients.
Methods: 532 subjects, 38 men and 494 women, who attended a weight loss program in a local obesity clinic were analyzed. Height, weight, BMI, WHR and obesity index were measured or calculated. Body composition was measured by bio-impedance analysis. Genotype of polymorphism in codon 27 was analyzed by PCR-RFLP method. Serum concentrations of fasting glucose, total and HDL cholesterol, and triglyceride were determined by autobiochemical analyzer.
Results: The Genotype distributions of gene were QQ type 81.3%, QE type 17.9% and EE type 8%. Therefore, the frequency of E allele of gene was 0.170 in the total subjects. The frequency of the variant genotype(QE+EE) was significantly higher in obese group() compared with non-obese group(p=0.027). Weight was significantly higher in variant(QE+EE) type compared with normal(QQ) type in total subjects(p=0.001), male(p=0.022) and female(p=0.013). BMI, obesity index and WHR were also significantly higher in QE+EE type. Body fat man was significantly higher in QE+EE type in total subjects(p=0.005) and female(p=0.027). When forward stepwise regression analysis was used to create a model of risk predictors of obesity(), QE+EE type of gene was found to be a significant risk factor for obesity (p=0.042, ORs 1.597).
Conclusions: QE+EE genotype of was associated with increased obesity indices and might be a significant risk factor for obesity.
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KEYWORD
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β2-Adrenergic Receptor, polymorphism, Gln27Glu, obesity
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